Versatility to address multiple modalities and MoA

 No matter the complexity of your project—from designing a small molecule inhibitor or a protein-protein interaction (PPI) inhibitor to finding molecular glues—our platform is built to deliver.

We don't rely on a single approach. Instead, we utilize an integrated, proprietary suite of tools that combines trusted methods with advanced quantum mechanics, ensuring we apply the exact blend of techniques needed to achieve your specific objectives.

  • Our unique blend of familiar tools such as FEP and Boltz2, with our advanced quantum methods such as QMMM, DFT and post-Hartree Fock calculations in our Molecular Modeling engine, provide high resolution understanding of the active site. 

    Unlike other technologies, we can model the transition state with unparalleled accuracy enabling the design of compounds with exquisite potency and selectivity, combined with valuable insights that drive compound optimisation. 

    Kuano has repeatedly delivered such outcomes across target classes such as metalloproteases, methyltransferases, and phosphatases. For our case studies click here

  • HitGen+

    CandidateCreator

    FEP

    Virtual Screening

    Molecular Modelling

  • HitGen+

    CandidateCreator

    FEP

    PharmacoJump

    ActivityMapper

    Molecular Modeling

  • Only advanced quantum methods can reveal the influence of other residues, the environment, and ligand chemistry on covalent reactivity, This holistic picture enables predictivity beyond the simplistic world of ‘residue + warhead’ to explain real-world observations. 

    At Kuano, we create ‘quantum fingerprints’ that describe the system at quantum level, from which we can pick out the reactivity. (show pic)

    This approach is amino-acid agnostic: we can look as easily ‘beyond Cysteine’ than at cysteine; we can explore novel warheads . The first step was to prove that our platform explained covalent reactivity in a way that no other methods could: check out our case study on JAK3 and EGFR  here

  • HitGen+

    CandidateCreator

    FEP

    PharmacoJump

    Molecular Modeling

  • HitGen+

    Virtual Screening

    Molecular Modeling